多潘立酮联合阿米替林治疗消化不良的效果观察

目的：探讨多潘立酮联合阿米替林治疗消化不良的临床效果，进一步指导临床治疗。方法：选取2009年1月-2012年1月本院收治的100例消化不良患者随机分为两组，每组50例，对照组给予单纯多潘立酮治疗，观察组给予多潘立酮联合阿米替林治疗，对比两组治疗疗效。结果：研究结果显示，观察组痊愈35例，有效12例，总有效率94％；对照组痊愈22例，有效17例，总有效率78％。观察组总有效率显著高于对照组，差异具有统计学意义（P〈0．05）。观察组未出现腹部痉挛、口干、腹泻、头痛和神经过敏等不良反应，仅1例女性患者出现泌乳反应；对照组出现2例腹泻症状反应。不良反应经药物减量或停药处理后均好转，未出现其他不良反应。结论：多潘立酮联合阿米替林治疗消化不良较单纯采用多潘立酮进行治疗的临床效果更佳，且安全性好，值得在临床进行推广应用。

The Effect of Domperidone Combined Amitriptyline in the Treatment of Dyspepsia

Objective： To discuss the clinical effect on domperidone combined amitriptyline on the treatment of dyspepsia, further guide treatment. Method： 100 eases of patients with dyspepsia in January 2009 - January 2012 in our hospital were randomly divided into two groups, 50 cases in. each group, control group was given domperidone treatment, observation group was given domperidone combined amitriptyline treatment, the treatment efficacy of two groups were compared. Result： The results showed that the observation group of 50 cases , 35 cases cured, 12 cases effective, the total effective rate was 94%; the control group orS0 cases, 22 cases cured, 17 eases effective, total effective rate was 78%. The observation group total effective rate was significantly higher than that of control group, differences had statistically significant （ P〈0.05 ） . The observation group did not appear abdominal cramps, dry mouth, diarrhea, adverse reactions such as headaches and nervousness, 1 case of female patients had mammary response; The control group, 2 cases of diarrhea symptoms. Adverse reactions after dosage reduction or withdrawal treatment were better, did not appear other reactions. Conclusion： The effect of domperidone combined amitriptyline on the treatment of dyspepsia are better than simply adopting domperidone , and safety and good, is worth popularizing in clinical application.