子宫全切术对卵巢功能影响的临床研究

目的：通过子宫肌瘤剔除与子宫全切术治疗子宫肌瘤患者的临床对比研究,探讨子宫全切术对患者卵巢功能的影响。方法：2011年1月-2013年1月在本院住院的90例子宫肌瘤患者按就诊顺序分成子宫肌瘤剔除组和子宫全切组,监测患者术前、术后6个月、12个月雌二醇（E2）、促卵泡激素（FSH）、黄体生成素（LH）水平,观察卵巢功能。结果：两组患者术前性激素（E2、FSH、LH）比较差异无统计学意义（t=0.17、0.65、1.04,P〉0.05）,而术后6个月,两组性激素比较差异有统计学意义（t=6.14、4.15、3.71,P〈0.05）。术后12个月,两组性激素比较差异有统计学意义（t=5.12、3.89、4.65,P〈0.05）。术后6个月子宫肌瘤剔除组月经不规律（月经量少、稀发或周期延长）均明显少于子宫全切组,差异有统计学意义（字2=1.43,P〈0.05）。术后12个月子宫肌瘤剔除组月经不规律明显少于子宫全切组,差异有统计学意义（字2=5.29,P〈0.05）。结论：行子宫肌瘤剔除术治疗子宫肌瘤,卵巢内分泌功能稳定,而子宫全切术直接影响卵巢功能。

Clinical Study of the Impact of Hysterectomy on Ovarian Function

Objective： To explore the impact of hysterectomy on ovarian function in patients by comparative study on the treatment of hysterectomy and uterine fibroids removed surgery on patients with uterine fibroids.Mcthod： Ninty patients with uterine fibroids were randomly divided into the myomectomy group and the hysterectomy group according to treatment sequence from January 2011 to January 2013.Estradiol （ E2 ）, follicle-stimulating hormone （ FSH ） and luteinizing hormone （ LH ） levels of patients before and 6 months, 12 months after treatment were monitored, and the ovarian function were observed.Result： The sex hormones （ E2, FSH, LH ） of patients before surgery of the two groups had no significant difference （ t=0.17, 0.65, 1.04, P〉0.05 ） .Six months after surgery, the difference of the two groups were statistically significant （ t=6.14, 4.15, 3.71, P〈0.05 ） .After 12 months, the difference of the two groups were statistically significant （ t=5.12, 3.89, 4.65, P〈0.05 ） .Six months later, irregular menstruation （ menstruation, thin hair or extend the cycle ） of the myomectomy group was significantly less than that of the hysterectomy group, the difference was statistically significant （X2=1.43, P〈0.05 ） .Irregular menstruation of the myomectomy group was significantly less than that of the hysterectomy group 12 monthslater, the difference was statistically significant （X2=5.29, P〈0.05）.Conclusion： Myomectomy in treatment ofuterinefibroids, ovarian endocrine function is stability, but hysterectomy direct impact on ovarian function.