氨溴索雾化及静滴联合用药与单独用药治疗小儿支气管肺炎的效果比较观察

目的探讨氨溴索雾化及静滴联合用药与单独用药治疗小儿支气管肺炎的效果。方法选择2011-09—2013-03该院收治的101例支气管肺炎患儿，按入院时间半随机分为A、B、C三组。在综合治疗的基础上，A组采用氨溴索氧化雾化联合静脉滴注治疗，B组采用氨溴索氧化雾化治疗，C组采用氨溴索静脉滴注治疗，比较三组总有效率、胸片改变情况、住院天数和症状改善时间。结果（1）三组疗效比较差异均无统计学意义（P〉0．05）；（2）三组临床指标（症状、体征消失时间和住院天数）比较差异均无统计学意义（P〉0．05）；（3）三组治疗后胸片情况比较差异均无统计学意义（P〉0．05）；（4）三组对C反应蛋白（CRP）、白细胞计数（WBC）的影响比较差异均元统计学意义（P〉0．05）。两种给药途径联合应用治疗后hs-CRP恢复正常的例数明显多于单独应用者（P〈0．05）。结论氨溴索氧化雾化联合静脉滴注治疗小儿支气管肺炎其疗效、临床指标、治疗后胸片、WBC与CRP的变化并不优于单用静脉滴注或氧驱动雾化吸入治疗，仅对hs-CRP的恢复存在优势，认为两种用药途经联合应用既浪费药源，增加病人负担，又浪费护士人力资源。

Combination use of oxidation-atomization inhalation and intravenous drop of ambroxol and their separate use in the treatment of children bronchial pneumonia: an analysis of therapeutic effect

Objective To explore the therapeutic effect of combination use of oxidation-atomization inhala- tion and intravenous drop of ambroxol and their separate use in the treatment of children bronchial pneumonia. Meth- otis From September 2011 to March 2013 101 children with bronchial pneumonia, according to the admission time, were randomly divided into A, B, C groups. On the basis of comprehensive treatment, group A was treated with oxi- dation-atomization inhalation combined with intravenous drop of ambroxol, group B with oxidation-atomization inhala- tion of ambroxol, group C with intravenous drop of ambroxol. The comparison between 3 groups was performed of the total efficiency, the change of chest X-ray, days of hospitalization and symptom improvement time. Results （ 1 ） There was no statistically difference in total effective rate between 3 groups （P 〉 0.05 ） ; （2）There was no statistically difference in clinical indexes （ symptom improvement, day of hospitalization） between 3 groups （ P 〉 0.05 ） ; （ 3 ） After 7 days of treatment there was no statistically difference in change of chest X-ray between 3 groups （P 〉 0.05 ） ; （4）No statistical significance among the 3 groups in changes WBC and CRP（P 〉 0. 05 ）. But the number of cases of hs-CRP returned to normal in A group were more than B or C group （ P 〈 0.05 ）. Conclusion The efficacy and the clinical index changes after treatment, WBC, chest X-ray and CRP of ambroxol oxidatlon-atomization inhalation combined with intravenous infusion of ambroxol in the treatment of children bronchial pneumonia is not superior to treatment with intravenous infusion or oxygen-driven inhalation of ambroxol, only there is advantage to restore hs-CRP, consider the combination of two routes of drug use should waste pharmaceutical sesource, increase the burden of patients, and waste of the nursing human resource.