Ulnar nerve repair by end-to-side neurorrhaphy on the median nerve with interposition of a vein: an experimental study |
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Authors: | Manasseri Benedetto Raimondo Stefania Geuna Stefano Risitano Giovanni D'Alcontres Francesco Stagno |
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Affiliation: | Chirurgia Plastica, Universitá di Messina, 80 via Comunale Sperone, 98158 Messina, Italy. |
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Abstract: | Our study used a rat animal model to verify that Schwann cell migration, collateral axonal sprouting, and regeneration were not hindered by interposition of a 10-mm vein segment between the distal stump of the transected ulnar nerve and the donor median nerve in end-to-side reconstruction. Reconstructed nerves were withdrawn at 7, 14, 30, and 60 days after surgery, then analyzed by confocal laser microscopy after immunolabeling with anti-neurofilament-200 kD (an axonal marker) and anti-S100 (a glial marker) antibodies. Results are reported at 7, 14, 30, and 60 days after surgery. Our observations indicate that chemotactic factors that stimulate end-to-side nerve regeneration can exert their action at this distance. These findings suggest a possible clinical application for this surgical technique in cases when the severed nerve stump is far from the potential donor nerve. |
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