| 肾虚证与糖尿病遗传易感性的关联 |
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| 引用本文： | 谭从娥,王米渠,张辉.肾虚证与糖尿病遗传易感性的关联[J].中医杂志,2011,22(21):1836-1839. |
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| 作者姓名： | 谭从娥 王米渠 张辉 |
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| 作者单位： | 1. 陕西中医学院中医诊断学教研室,陕西省成阳市世纪大道,712046
2. 成都中医药大学中医遗传学研究室 |
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| 基金项目： | 陕西省教育厅专项科研计划项目，国家自然科学基金 |
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| 摘 要： | 目的探讨肾虚证与2型糖尿病(T2DM)遗传易感性的关联性。方法从62个T2DM家系中筛选出年龄≥35岁的先证者(62例)的一、二级亲属188例,将包括先证者在内的250例家系成员分为T2DM组(136例)、糖耐量异常组(52例)和家系健康组(62例);并选取无糖尿病家族史且糖耐量正常者60例作为非家系健康对照组。按照68项肾虚辨证因子调查表的内容,对各组症状和体征作正常为"0"、异常为"1"的二值化计分,比较各组肾虚因子总计分的差异,并对各组排前10位的肾虚辨证因子进行统计。结果 T2DM组的平均年龄与其他3组比较差异有统计学意义(P<0.01),4组之间的性别差异无统计学意义(P>0.05),T2DM组的肾虚辨证因子总分显著高于糖耐量异常组(P<0.01),家系健康组的肾虚相关因子总分高于非家系健康对照组(P<0.01)。腰痛症状在T2DM组、糖耐量异常组、家系健康组中出现频率均列于前10位,分别占54.8%、53.2%和19.4%,而在非家系健康对照组中出现频率非常低。结论肾虚或肾虚体质在糖尿病家系中有可遗传倾向,此倾向与家系亲属糖尿病的遗传易感性有密切的联系。
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| 关 键 词： | 肾虚 2型糖尿病 遗传易感性 家系 |
Discussion on the Association of Kidney Deficiency with Diabetes Genetic Susceptibility |
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| TAN Cong'e,WANG Miqu,ZHANG Hui.Discussion on the Association of Kidney Deficiency with Diabetes Genetic Susceptibility[J].Journal of Traditional Chinese Medicine,2011,22(21):1836-1839. |
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| Authors: | TAN Cong'e WANG Miqu ZHANG Hui |
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| Institution: | 1. Teaching and Research Section of TCM Diagnostics, Shaanxi University of Chinese Medicine, Xianyang 712046; 2.Research Department of Genetics, Chengdu University of Chinese Medicine) |
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| Abstract: | Objective To explore the association of kidney deficiency with genetic susceptibility of type II diabetes mellitus (T2DM). Methods Totally 188 cases of the first and second degrees of relatives of 62 probands, older than or equal to 35 years old, from the 62 T2DM families were screened out. The 250 family members, with the probands included, were divided into T2DM group (136 cases), abnormal glucose tolerance group (52 cases), and healthy family group (62 cases). In addition, the other 60 people with normal... |
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| Keywords: | kidney deficiency type II diabetes mellitus (T2DM) genetic susceptibility family tree |
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