Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia

We present two pregnancies associated with normal live births and theunusual concomitance of chorangioma and placental vascular malformationwith mesenchymal hyperplasia. The enlarged placenta had the characteristicfindings of chorangioma, dilated and varicose chorionic vessels andmultiple vesicle-like villi containing hyaluronic acid. The vesicle-likevilli showed diploid cellular DNA contents. Molecular genetic analysisusing the polymerase chain reaction amplification of polymorphicmicrosatellite markers confirmed genetic identity among the chorangioma,the vesicle-like villi and the fetus. Both pregnancies were complicated bypolyhydramnios, pre-term labour and prematurity. One neonate suffered fromanaemia and thrombocytopenia. Another neonate suffered fromhaemangiomatosis. Our cases demonstrate that concomitant chorangioma andplacental mesenchymal hyperplasia are genetically identical to the fetusand can coexist with a normal viable fetus. Since haemangiomas,chorangiomas, chorionic vessels and villi mesenchymal cells are all derivedfrom the mesoderm, a combination of fetal haemangiomas, placental vascularmalformation, chorangiomas and placental mesenchymal hyperplasia mayrepresent a mixed form of congenital malformation of the mesoderm.