Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia |
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Authors: | Chen CP; Chern SR; Wang TY; Huang ZD; Huang MC; Chuang CY |
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Institution: | Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China. |
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Abstract: | We present two pregnancies associated with normal live births and the
unusual concomitance of chorangioma and placental vascular malformation
with mesenchymal hyperplasia. The enlarged placenta had the characteristic
findings of chorangioma, dilated and varicose chorionic vessels and
multiple vesicle-like villi containing hyaluronic acid. The vesicle-like
villi showed diploid cellular DNA contents. Molecular genetic analysis
using the polymerase chain reaction amplification of polymorphic
microsatellite markers confirmed genetic identity among the chorangioma,
the vesicle-like villi and the fetus. Both pregnancies were complicated by
polyhydramnios, pre-term labour and prematurity. One neonate suffered from
anaemia and thrombocytopenia. Another neonate suffered from
haemangiomatosis. Our cases demonstrate that concomitant chorangioma and
placental mesenchymal hyperplasia are genetically identical to the fetus
and can coexist with a normal viable fetus. Since haemangiomas,
chorangiomas, chorionic vessels and villi mesenchymal cells are all derived
from the mesoderm, a combination of fetal haemangiomas, placental vascular
malformation, chorangiomas and placental mesenchymal hyperplasia may
represent a mixed form of congenital malformation of the mesoderm.
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