血管损伤修复与炎症反应的研究进展

血管损伤后,内皮细胞、平滑肌细胞以及炎症细胞可以产生多种细胞因子、趋化因子、细胞黏附分子和蛋白水解酶,引起白细胞黏附、血小板的激活和血栓形成,血管平滑肌细胞的增生、迁移和凋亡以及细胞外基质的增生和重构。炎症在血管损伤后内膜增生以及血管成形术和支架置入术后血管再狭窄中起重要作用。本综述主要介绍各种炎症介质在血管损伤修复中的重要作用的新进展。

Inflammatory Response After Vascular Injury

After vascular injury,endothelial cell,smooth muscle cell and inflammatory cell can synthethized a number of cytokines,chemokines,cell adhesion molecules and proteolytic enzymes,which result in leukocyte adhesion,platelet activation,thrombosis,and subsequent proliferation,migration,apoptosis of vascular smooth muscle cell.Extracellular matrix will hence accumulate and undergoing a process which called vascular remodeling.Inflammation plays a critical role in the intima hyperplasia after vascular injury and restenosis such as angioplasty or stent implantation.This review mainly describes the pivotal role of inflammatory mediator in repairing process after vascular injury.