胃舒胶囊治疗幽门螺杆菌相关性胃炎的实验研究

目的:观察胃舒胶囊对幽门螺杆菌相关性胃炎的治疗作用.方法:用幽门螺杆菌菌液给大鼠灌胃制备幽门螺杆菌相关性胃炎模型.灌胃给药治疗结束一个月后,取胃窦部组织进行直接涂片法、快速尿素酶实验及细菌培养检测细菌定植情况,另取胃壁组织观察病理学变化.结果:胃舒胶囊三个剂量组的幽门螺杆菌根除率分别为0.28g/kg组40%,0.5g/kg组53.3%,0.84g/kg组93.3%,同时胃窦部黏膜炎症均有不同程度的改善.结论:胃舒胶囊对幽门螺杆菌相关性胃炎有治疗作用.

Experimental study on effects of Weishu Capsule (胃舒胶囊) on gastroduodenal disease associated with Helicobacter pylori

Objective: To investigate the curative effects of Weishu Capsule (WSC) on treating gastroduodenal disease associated with. Methods: 60 Wistar rats were used to established the rat model of H.pylory infection. One week after the last infection, 50 rats with H.pylor serum antibody positive were used as experimental animals in this study. They were randomly divided into four groups: model control group(10 rats); low dose of WSC group(10 rats); medium dose of WSC group(10 rats); high dose of WSC group(10 rats); Ten rats were used as normal control group animals in this study. One week after the last bacteria inoculum, the normal control group were not dealt with, and the model control group were inoculated orally with water, but the other groups were inoculated orally with different dose of WSC, once a day for 10 days. A month after the last treatment, all rats were killed and observed the results of eradiction on H. pylori and the pathological changes of gastric antrum mucosa. Histology and H. pylori colonization were assessed by basic fuchsin staining, Urease test, H. pylori culture and HE staining. Pathological changes of gastric antrum mucosa were graded. Results: The eradiction rate of H. pylori in remedial groups respectively were:model control group 0; low dose group of WSC 40%, medium dose group of WSC 53.3%, high dose group of WSC 93.3%, they were significant differences in groups treatment with WSC at three different doses. The active inflammation of gastriv antrum mucosa had been obviously improved and chronic inflammation had been slightly improved in rats received drug therapy. Conclusion: WSC has an effect on gastroduodenal disease associated with H. pylori.