Post-weaning social isolation of rats leads to a diminution of LTP in the CA1 to subiculum pathway |
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| Authors: | Roberts L Greene J R T |
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| Affiliation: | Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. l.roberts@bristol.ac.uk |
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| Abstract: | Post-weaning social isolation of rats produces psychological and physiological changes that are relevant to schizophrenia. Here, we report that long-term potentiation (LTP) in the CA1 to subiculum pathway is lower by 34%, (P<0.0001) in brain slices from isolates compared with those from socially housed rats. We also report that LTP in this pathway is NMDA receptor-dependent. |
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| Keywords: | Schizophrenia Subiculum Long-term potentiation NMDA receptor |
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