Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation |
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Authors: | L. KEMÉ NY,M. CSATO,P. BRAQUET,A. DOBOZY |
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Affiliation: | Department of Dermatology, Albert Szent-Gy?rgyi Medical University, Szeged, Hungary. |
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Abstract: | The effect of BN 52021, a selective platelet activating factor (PAF) antagonist was studied on dithranol-induced irritant dermatitis. Pretreatment of the skin with 0.45% BN 52021 ointment significantly suppressed the decrease in capillary resistance, rise in skin temperature and increase in skin-fold thickness produced by dithranol. |
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