| 檞皮素对白细胞功能与代谢的影响 |
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| 引用本文： | 李福刚,王兆钺,阮长耿,顾庆礼,张健.檞皮素对白细胞功能与代谢的影响[J].中国药理学通报,1991(6). |
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| 作者姓名： | 李福刚 王兆钺 阮长耿 顾庆礼 张健 |
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| 作者单位： | 江苏血液研究所苏州医学院血栓与止血研究室 江苏血液研究所苏州医学院附属一院血液病研究室 江苏血液研究所苏州医学院附属一院血液病研究室 苏州 |
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| 摘 要： | 檞皮素(0.05～0.20mmol/L,终浓度)在体外明显抑制花生四烯酸(AA),白三烯B_4(LTB_4),广西眼镜蛇毒第Ⅳ组分(Co-bra venom)诱导的人白细胞聚集和前列腺素E_2(PGE_2),血栓烷B_2(TXB_2)的生成,剂量与效应相关,其抑制AA,LTB_4,Cobra ve-nom诱导人白细胞聚集的ID_(50)分别为68μmol/L,59μmol/L,61μmol/L。当檞皮素终浓度达到0.50mmol/L时,它也能抑制AA,LTB_4,Cobravenom刺激的人白细胞溶菌酶的释放反应。
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| 关 键 词： | 檞皮素 白细胞聚集 前列腺素E_2 血栓烷B_2 溶菌酶 |
THE INFLUENCE OF QUERCETIN ON PMN METABOLISM AND FUNCTION |
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| Li Fugang,Wang Zhaoyue,Ruan Ghanggen.THE INFLUENCE OF QUERCETIN ON PMN METABOLISM AND FUNCTION[J].Chinese Pharmacological Bulletin,1991(6). |
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| Authors: | Li Fugang Wang Zhaoyue Ruan Ghanggen |
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| Abstract: | Quercetin (0.05~0.20 mmol/L, final concentration) obviously inhibited the aggregation and production of PGE2 and TXB2 of human PMN which were induced by AA ( 0.66 mmol/L), LTB4 ( 0.002 mmol/L) and the fourth composition of cobra venom of Guangxi Province ( 4.8mg/L) in vitro. These effects were dose dependent, the IDg50 of PMN aggregation induced by AA, LTB4 and the fourth composition of cobra venom of Guangxi Province was 68μmol/L, 59μmol/L and 61μmol/L respectively. At the concentration of 0.50μmol/L, it can also inhibit lysozyme release of PMN induced by AA, LTB4 and the fourth composition of cobra venom of Guangxi Province. |
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| Keywords: | Quercetin PMN aggregation Prostaglandin E2 Thromboxane B2 Lysozyme |
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