广西壮、汉族绝经后妇女维生素D受体基因多态性的研究

目的　探讨维生素D受体 (vitaminDreceptor,VDR)基因多态性 ,以获得在广西壮、汉族妇女VDR受体基因频率分布数据。方法　用聚合酶链反应 -限制性片段长度多态性 (polymerasechainreaction ristrictionfragmentlengthpolymorphism ,PCR RFLP)方法检测壮、汉族绝经后妇女各 80例的VDR基因型。结果　壮、汉族绝经后妇女BB、Bb和bb基因型频率分别为 0 0 6 5比 0 0 5 4、0 739比 0 6 6和 0 1 96比 0 2 86 (P >0 0 5 ) ;壮、汉族绝经后妇女B和b等位基因频率分别为 0 4 31比 0 381和 0 5 6 9比0 6 1 9(P >0 0 5 )。结论　广西壮、汉族绝经后妇女VDR基因多态性无显著性差异。

A study of vitamin D receptor gene polymorphism in the Zhuang and Han ethnic postmenopausal women in Guangxi

Obsjective To investigate the distribution of vitamin D receptor(VDR) genotypes in the Zhuang and Han ethnic group postmenopausal women in Guangxi Methods The VDR genotypes were determined by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP) using the Bsm I enzyme in 80 Zhuang and 80 Han postmenopausal women Results The frequences of BB,Bb and bb genetypes were 0 065 vs 0 054,0 739 vs 0 66 and 0 196 vs 0 286 in the Zhuang and Han postmenopausal women,respectively (P>0 05);the frequence of B and b alleles were 0 431 vs 0 381and 0 569 vs 0 619,respectively Conclution There was no significant difference in the vitamin D receptor gene polymorphism between Zhuang and Han postmenopausal women in Guangxi