| CD44V6在非小细胞肺癌中表达的临床研究 |
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| 引用本文： | 陈宁,任爱平,王蒙琴,魏枫.CD44V6在非小细胞肺癌中表达的临床研究[J].包头医学院学报,2001,17(1):14-16. |
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| 作者姓名： | 陈宁 任爱平 王蒙琴 魏枫 |
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| 作者单位： | 包头医学院一附院呼吸科, |
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| 摘 要： | 目的：探讨变异型白细胞分化抗原（VD44V6）在非小细胞肺癌（NSCLC）中的表达情况以及其与肺癌浸润和转移的关系。方法：采用免疫组化SP法，对37例NSCLC组织进行CD44V6的检测。结果：CD44V6表达与NSCLC组织学分型无明显相关性（P＞0．05）；同NSCLC分级无关（P＞0．05）；按UTCC－TNM分期，Ⅱ期和Ⅲ期中CD44V6表达显著高于I期（P＜0．05）；与未转移者相比，发生淋巴结转移的肺癌组织中CD44V6表达明显提高（P＜0．01）。结论：CD44V6阳性表达可能对临床评估非小细胞肺癌进展及淋巴结转移具有一定意义。
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| 关 键 词： | 非小细胞肺癌 白细胞分化抗原44变异型 免疫组化 |
| 文章编号： | 1006-740X(2001)01-0014-03 |
| 修稿时间： | 2000年10月13日 |
Expression of CD44V6 Genes in Non-small Cell Lung Cancer and Their Clinical Study |
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| Chen Ning,Ren Aiping,Wang Mengqin,et al.Expression of CD44V6 Genes in Non-small Cell Lung Cancer and Their Clinical Study[J].Journal of Baotou Medical College,2001,17(1):14-16. |
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| Authors: | Chen Ning Ren Aiping Wang Mengqin |
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| Abstract: | Objective:To study the expression of CD44V6 in non-small cell lung cancer (NSCLC)and to understand the correlation of expression of CD44V6 with the histologic types,degrees of differentiation,clinical stages as well as lung cancer in vasion and metastasis.Methods:The expression of CD44V6 was observed in 37 NSCLC using anti CD44V6 monoclonal antibody by SP immunohisto chemical method. Result:CD44V6 was mainly expressed in NSCLC.The expression of CD44V6 is independent from tumor histopathological grading (P＞0.05).In different tumor stages,expression of CD44V6 in stage Ⅱ and stage Ⅲ were much higher than stage Ⅰ (P＜0.05).Compared with lung cancer without metastasis,lung cancer with lymphnode metastasis showed strang expression of CD44V6(P＜0.01).Conclusion:Expression of CD44V6 may be of great significance for the evaluation of the progress,degree of differentiation and lymphnode metastasis，of non small cell lung cancer. |
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| Keywords: | non small cell lung cancer CD44V6 immunohistochemistry |
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