| 内毒素血症大鼠颈迷走神经传出放电变化 |
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| 引用本文： | 黄健,杨志焕. 内毒素血症大鼠颈迷走神经传出放电变化[J]. 第三军医大学学报, 2005, 27(9): 850-852 |
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| 作者姓名： | 黄健 杨志焕 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所第四研究室,创伤、烧伤与复合伤国家重点实验室,重庆,400042;第三军医大学大坪医院野战外科研究所第四研究室,创伤、烧伤与复合伤国家重点实验室,重庆,400042 |
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| 摘 要： | 目的观察内毒素血症时大鼠颈迷走神经传出放电的变化.方法SD大鼠随机分为两组:内毒素组静脉注射内毒素5 mg/kg;对照组注射等容量生理盐水.应用神经电生理技术,记录并分析内毒素注射后30 min、1、2、4 h颈迷走神经传出放电频率的改变.结果两组基础放电差异无显著性意义(P＞0.05).大鼠注射内毒素后各时间点放电频率明显升高,与基础放电及注射生理盐水组的对应时间点相比,差异有显著性意义(P＜0.05).结论内毒素血症时颈迷走神经传出活动增强,这种改变可能是机体发挥其内源性抗炎保护作用的途径之一.
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| 关 键 词： | 迷走神经 内毒素血症 传出放电 |
| 文章编号： | 1000-5404(2005)09-0850-03 |
| 修稿时间： | 2004-07-02 |
Changes of cervical vagal efferent discharge induced by lipopolysaccaride in rats |
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| HUANG Jian,YANG Zhi-huan. Changes of cervical vagal efferent discharge induced by lipopolysaccaride in rats[J]. Acta Academiae Medicinae Militaris Tertiae, 2005, 27(9): 850-852 |
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| Authors: | HUANG Jian YANG Zhi-huan |
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| Abstract: | Objective To investigate the changes of cervical vagal efferent discharge induced by lipopolysaccaride in rats. Methods Ten rats were randomly divided into two groups, receiving lipopolysaccaride (5 mg/kg) or normal saline through intravenous injection. Frequency of cervical vagal efferent discharge was recorded at 30 min, 1, 2 and 4 h after the injection. Results The frequency of cervical vagal efferent discharge was significantly increased after LPS injection (P<0.05) while no significant changes after saline injection. Conclusion LPS enhanced the activation of cervical vagal efferent discharge. Vagus might play an important role when systemic inflammatory response syndrome occurs. |
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| Keywords: | vagus nerve lipopolysaccaride efferent discharge |
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