| 不同治法方药对激素性股骨头坏死鸡成骨 相关因子的影响 |
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| 引用本文： | 孔祥英,万蓉,李莉,林诗富,郭炜,林娜,孔焕宇,陈卫衡.不同治法方药对激素性股骨头坏死鸡成骨 相关因子的影响[J].中国中药杂志,2011,36(5):614-617. |
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| 作者姓名： | 孔祥英 万蓉 李莉 林诗富 郭炜 林娜 孔焕宇 陈卫衡 |
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| 作者单位： | 1. 中国中医科学院,中药研究所,北京,100700
2. 中国中医科学院,望京医院,北京,100102 |
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| 基金项目： | 国家自然科学基金项目(30472131) |
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| 摘 要： | 目的:通过观察健脾化痰、活血通络(健脾)与补肾壮骨、活血通络(补肾)2种不同治法方药对激素性股骨头坏死鸡成骨因子骨形成蛋白(BMP)2、转化生长因子(TGF)β1及其下游蛋白Smads的影响,比较探讨其防治股骨头坏死的作用机制.方法:48只来杭鸡经胸肌注射甲基氢化泼尼松建立激素性股骨头坏死模型后,随机分为模型组、健脾组和补肾组,另16只来杭鸡设为正常对照组,4个实验组在造模同时分别灌胃生理盐水和相应中药.给药8周和16周后取双侧股骨头,免疫组织化学法检测BMP2,TGFβ1和Smad4,7蛋白表达.结果:与正常组相比,模型组股骨头BMP2,TGFβ1和Smad4阳性细胞计数显著减少、Smad7明显增加;与模型组相比,健脾组8周时BMP2,TGFβ1和Smad4阳性细胞计数显著增多、Smad7明显减少,与补肾组在16周时的作用相类似.结论:健脾与补肾2种不同治法方药均能通过调节股骨头内成骨因子BMP2,TGFβ1和Smad4,7蛋白表达来促进股骨头的修复,防治股骨头坏死;健脾方药比补肾方药起效时间更早.
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| 关 键 词： | 股骨头坏死 BMP2 TGFβ1 Smads |
| 收稿时间： | 2010/12/22 0:00:00 |
Effect of different treating principles and formulas on expression of osteogenic factors in steroid-induced osteonecrosis of femoral head of chichen |
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| KONG Xiangying,WAN Rong,LI Li,LIN Shifu,GUO Wei,LIN N,KONG Huanyu and CHEN Weiheng.Effect of different treating principles and formulas on expression of osteogenic factors in steroid-induced osteonecrosis of femoral head of chichen[J].China Journal of Chinese Materia Medica,2011,36(5):614-617. |
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| Authors: | KONG Xiangying WAN Rong LI Li LIN Shifu GUO Wei LIN N KONG Huanyu and CHEN Weiheng |
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| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China |
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