| 小檗碱对急性缺血心肌的保护作用 |
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| 引用本文： | 房辉,汪晖,李泱.小檗碱对急性缺血心肌的保护作用[J].咸宁医学院学报,2004,18(5):308-311. |
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| 作者姓名： | 房辉 汪晖 李泱 |
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| 作者单位： | 武汉大学医学院药理学系，武汉大学医学院药理学系，华中科技大学同济医院 湖北武汉430071，湖北武汉430071 |
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| 摘 要： | 目的探讨小檗碱对急性缺血心肌的作用。方法用单相动作电位记录技术 ,记录兔在急性缺血状态时三层心肌单相动作电位 (MAP)的改变及使用小檗碱后的变化。结果小檗碱组缺血时动作电位振幅 (MAPA)与对照组相比变化较小 ,2相平台未见完全消失 ,MAP形态未呈典型的三角形改变。三层心肌跨室壁复极离散度 (TDR)降低 (P <0 .0 5 )。早期后除极 (EAD)及缺血性心律失常的发生率显著降低 (P <0 .0 5 )。结论小檗碱对急性缺血心肌具有保护作用
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| 关 键 词： | 小檗碱 急性缺血心肌 保护作用 单相动作电位 改变 缺血性 早期后除极 消失 记录 形态 |
| 文章编号： | 1008-0635(2004)05-0308-04 |
| 修稿时间： | 2004年9月15日 |
Protective Effects of Berberine on Myocardium Suffered from Acute Ischemia |
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| FANG Hui,WANG Hui,LI Yang.Protective Effects of Berberine on Myocardium Suffered from Acute Ischemia[J].Journal of Xianning Medical College,2004,18(5):308-311. |
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| Authors: | FANG Hui WANG Hui LI Yang |
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| Abstract: | Objective To observe the effects of berbeine on myocardium suffered from acute ischemia in rabbit.Methods With the technique of monophasic action potential to observe the effects on MAP of three-tier myocardium during acute myocardial ischemia and the effects after berberine have been used.Results In the group of berberine,MAPA were changed relative diminutive in comparison with that in the control,and the 2-aspect platform did not disappear fully.The shap of MPA was not triangular.The TDR of three-tier myocardium were depress.The rates of EDA and arrhythm of acute ischemia were dropped markedly.Conclusion Berberine has protective effects on acute myocardial ischemia. |
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| Keywords: | Berberine Acute myocardial ischemia Transmural dispersion of repolarization Arrhythmia |
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