Serum Soluble Triggering Receptor on Myeloid Cells-1 (sTREM-1) is Elevated in Systemic Lupus Erythematosus but does not Distinguish Between Lupus Alone and Concurrent Infection |
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Authors: | Yair Molad Elisheva Pokroy-Shapira Tania Kaptzan Assaf Monselise Michal Shalita-Chesner Yehudit Monselise |
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Institution: | 1. Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Petach Tikva, Israel 2. Rheumatology Unit, Beilinson Hospital, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel 4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 3. Laboratory of Clinical Immunology, Beilinson Hospital, Rabin Medical Center, Petach Tikva, 49100, Israel
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Abstract: | We sought to determine serum triggering receptor expressed on myeloid cell-1 (sTREM-1) level in a cohort of patients with systemic lupus erythematosus (SLE). Serum sTREM-1 level of 98 patients with SLE and 49 healthy controls was assayed by ELISA. Serum sTREM-1 level was significantly elevated in a cohort of 78 unselected consecutively recruited patients with SLE (mean 1.1?±?2.8 ρg/ml, median 0.02 ρg/ml) compared to that of the controls (mean 0.11?±?0.3 ρg/ml, median 0 ρg/ml; p?<?0.0001). We also determined serum sTREM-1 level of 20 SLE patients with a concurrent infection (mean 0.6?±?1.1 ρg/ml, median 0.12 ρg/ml) and found it not statistically significant compared with that of the patients without infection. Serum sTREM-1 level did not correlate with SLE disease activity. Our finding of elevated serum sTREM-1 level suggests an increased shedding of TREM-1 in SLE and a possible novel pathway of innate immune response in autoimmunity. |
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