| 抗抑郁新药马来酸氟伏沙明的合成 |
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| 引用本文： | 于冰,吴范宏. 抗抑郁新药马来酸氟伏沙明的合成[J]. 中国药物化学杂志, 2004, 14(2): 99-101 |
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| 作者姓名： | 于冰 吴范宏 |
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| 作者单位： | 华东理工大学化学与制药学院,上海,200237 |
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| 摘 要： | 目的研究抗抑郁新药马来酸氟伏沙明的合成.方法以苯甲酸乙酯为起始原料,经取代、氨解、水解、成盐4步反应合成马来酸氟伏沙明(8).结果与结论以苯甲酸乙酯为起始原料,合成了马来酸氟伏沙明,总收率为51%.改进了中间体2-溴乙基邻苯二甲酰亚胺(4)的合成工艺.
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| 关 键 词： | 药物化学 工艺改进 化学合成 氟伏沙明 |
| 文章编号： | 1005-0108(2004)02-0099-03 |
Synthesis of a new antidepressant--fluvoxamine maleate |
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| YU Bing,WU Fan-hong. Synthesis of a new antidepressant--fluvoxamine maleate[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(2): 99-101 |
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| Authors: | YU Bing WU Fan-hong |
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| Abstract: | Aim To study on the synthesis of fluvoxamine maleate.Methods Fluvoxamine maleate was synthesized using ethyl benzoate as the starting material via four steps,such as substitution reaction,aminolysis,hydrolysis and salt formation,etc..Results and Conclusions The target compound was identified by spectroscopic analysis,and the overall yield was 51%.The preparative method of N-(2-bromoethyl) phthalimide (4) is improved. |
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| Keywords: | medicinal chemistry process improvement chemical synthesis fluvoxamine |
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