Prevalence of dysphosphoremia in patients admitted in intensive care unit with an impaired renal function |
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| Authors: | Joly L-M Troché G Trouiller P Boukhalil M Zazzo J-F |
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| Affiliation: | 1. Département d''anesthésie–réanimation chirurgicale, hôpital Antoine-Béclère, 157, rue de la porte-de-Trivaux, université Paris-Sud, 92140 Clamart, France;2. Département d''anesthésie–réanimation, hôpital Charles-Nicolle, CHU de Rouen, rue de Germont, 76031 Rouen, France;1. Department of Internal Medicine and Clinical Investigation Centre, University Hospital Saint Eloi, Montpellier 34295, France;2. Vascular Medicine Unit, Geneva University Hospital, Geneva, Switzerland;1. INRA, UR0050, Laboratoire de Biotechnologie de l’Environnement, Avenue des Etangs, Narbonne F-11100, France;2. Université de Lorraine, LSE, UMR 1120, Vandœuvre-lès-Nancy F-54505, France;3. CNRS, UMS 3562, Vandœuvre-lès-Nancy F-54501, France;4. LISBP – INSA de Toulouse, INSA/CNRS 5504 – UMR INSA/INRA 792, 135 Avenue de Rangueil, 31077 Toulouse CEDEX 04, France;1. Medical Department 2, Municipal Hospital Dresden-Friedrichstadt, 01067 Dresden, Germany;1. Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France;2. Service de réanimation médicochirurgicale, hôpital Louis-Mourier, AP–HP, 178, rue des Renouillers, 92700 Colombes, France;3. Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France;4. Service de pneumologie, hôpital européen Georges-Pompidou, AP–HP, 75015 Paris, France;5. Université Paris 13, Sorbonne Paris Cité, 93000 Bobigny, France;6. Service d’hématologie biologique, hôpital Avicenne, AP–HP, 93000 Bobigny, France;7. Service de dermatologie, hôpital Saint-Louis, AP–HP, 75010 Paris, France;8. Service de rhumatologie, hôpital Avicenne, AP–HP, 93000 Bobigny, France;9. Service de réanimation chirurgicale, hôpital Cochin, AP–HP, 74014 Paris, France;10. Service de réanimation médicale, hôpital Cochin, AP–HP, 74014 Paris, France;11. Service d’hématologie greffe, hôpital Saint-Louis, AP–HP, 75010 Paris, France;12. Service de médecine interne, hôpital Beaujon, AP–HP, 92110 Clichy, France;13. Département d’épidémiologie et de recherche clinique, hôpital Louis-Mourier, AP–HP, 92700 Colombes, France;1. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan;2. Division of Cardiology, National Hospital Organization Kobe Medical Center, Kobe, Japan;3. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan;4. Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan |
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| Abstract: | OBJECTIVE: To assess the frequency of dysphosphoremia in patients admitted in intensive care unit with an impaired renal function and to determine the associated risks factors. Study design. - Epidemiological prospective study. PATIENTS AND METHODS: The creatinine clearance and the phosphoremia were measured in 134 consecutive patients admitted in intensive care unit over a six-month period. Patients with chronic renal failure were excluded. Known risk factors for hypophosphoremia in intensive care unit were recorded. RESULTS: Seventy-nine out of one hundred thirty-four patients (59%) had an impaired renal function (arbitrarily defined by a creatinine clearance < 60 ml/min). The proportion of patients with impaired renal function that where hypo-, normo- (0.8 to 1.2 mmol/l) or hyperphosphoremic was 16, 34 and 50% respectively. Hypophosphoremia was severe (< 0.5 mmol/l) in 5 patients, all with impaired renal function. No risk factors usually associated with hypophosphoremia could be identified. CONCLUSION: As opposed to chronic renal failure patients who are mainly hyperphosphoremic, patients admitted in intensive care unit with an impaired renal function may present with a normo-, or hypophosphoremia. These dysphosphoremias are sometimes severe. Phosphate status should be promptly determined at admission. |
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