| HPLC法同时测定阿司匹林咀嚼片中阿司匹林和水杨酸的含量 |
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| 引用本文： | 冀宛丽,赵家太.HPLC法同时测定阿司匹林咀嚼片中阿司匹林和水杨酸的含量[J].海峡药学,2009,21(4):56-58. |
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| 作者姓名： | 冀宛丽 赵家太 |
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| 作者单位： | 1. 山西长治市药品检验所,长治,046000
2. 山西太行药业股份有限公司,长治,046000 |
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| 摘 要： | 目的用高效液相色谱法同时测定阿司匹林咀嚼片中阿司匹林和水杨酸的含量。方法采用Diamonsil C18色谱柱；以甲醇．醋酸．水（45：1：54）为流动相；流速：1．0mL·min-1，检测波长为275nm。结果阿司匹林线性范围：0．54～10．85μg（r=O．9999），平均回收率为100．9％．RSD为O．36％（n=5）；水杨酸线性范围：2．65-31．77μg·mL-1（r=1．0000），平均回收率为102．3％，RSD为2．O％（n=5）。结论此方法简便、快速、准确。值得推广应用。
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| 关 键 词： | 高效液相 阿司匹林 水杨酸 |
Simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets by HPLC |
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| JI Wan-Li,ZHAO Jia-Tai.Simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets by HPLC[J].Strait Pharmaceutical Journal,2009,21(4):56-58. |
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| Authors: | JI Wan-Li ZHAO Jia-Tai |
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| Institution: | JI Wan-Li, ZHAO Jia-Tai (1.Shanxi Taihang Pharmaceutical Co.Ltd, Changzhi 046000, Chinal 2.Shanxi Changzhi Institute for Drug Control, Changzhi 046000, China) |
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| Abstract: | OBJECTIVE An HPLC method for the simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets was established. METHODS Diamonsil C18 column was used with methyl alcohol- acetic acid-water（45 ： 1 ： 54）as mobile phase.The flow rate was 1.0mL· min-1 and detecting wavelength was 275nm. RESULTS The linear range of aspirin was 0.54 -10.85μg （r = 0.9999）and average recovery was 100.9 %, RSD = 0.36 % （n = 5） ; The linear range of salicylic acid was 2.65 - 31.77μg· mL- l（r = 1.0000） and average recovery was 102.3 %, RSD = 2.0 % （n = 5）. CONCLUSION The method was simple, fast and accurate. |
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| Keywords: | HPLC Aspirin Salicylic acid |
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