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Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8 |
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| Authors: | Sungjin Ko Jacquelyn O. Russell Jianmin Tian Ce Gao Makoto Kobayashi Rilu Feng Xiaodong Yuan Chen Shao Huiguo Ding Minakshi Poddar Sucha Singh Joseph Locker Hong-Lei Weng Satdarshan P. Monga Donghun Shin |
| Affiliation: | 1. Department of Developmental Biology, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania;2. Department of Pathology, Pittsburgh, Pennsylvania;3. Pittsburgh Liver Research Center, Pittsburgh, Pennsylvania;4. Ministry of Education Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, China;5. Department of Molecular and Developmental Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;6. Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany;7. Department of Pathology, Beijing You’an Hospital, Capital Medical University, Beijing, China;8. Department of Gastroenterology and Hepatology, Beijing You’an Hospital, Capital Medical University, Beijing, China;9. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania |
| Abstract: |  |
| Keywords: | Hepatic Development CDE Diet Signal Transduction A ablation ACLF acute-on-chronic liver failure BEC biliary epithelial cell CDE choline-deficient, ethionine supplemented CFP cyan fluorescent protein ChIP chromatin immunoprecipitation DMSO dimethyl sulfoxide dpf days postfertilization GFP green fluorescent protein H2B histone 2B HBV hepatitis B virus H3K9ac acetylation of histone H3 at lysine 9 kb kilo base LPC liver progenitor cell Mtz metronidazole NICD Notch intracellular domain qPCR quantitative polymerase chain reaction R regeneration |
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