自体角膜缘干细胞移植联合丝裂霉素对胬肉术后复发的影响

目的探讨显微镜下翼状胬肉切除加自体角膜缘干细胞移植联合丝裂霉素棉片使用与传统显微镜下单纯翼状胬肉切除术后疗效差异。方法 39例患者(46只眼)单纯翼状胬肉患者,随机分2组:单纯切除组23只眼使用显微镜下进行单纯翼状胬肉切除;联合手术组23只眼在手术显微镜下切除胬肉组织后0.02%丝裂霉素处理,取带有角膜缘干细胞的结膜瓣移植。术后随访12个月,观察胬肉复发情况。结果按胬肉术后的4种状态评定:联合手术组有2例复发,单纯切除组有8例复发。结论自体角膜缘干细胞移植加丝裂霉素手术与单纯胬肉切除术比较有明显的低复发率。

Effects of corneal limbal stem cells autograft transplantation combined with application of mitomycin on post-surgical recurrence of pterygium

Objective To investigate the therapeutic difference between microsurgical excision of pterygium combined with corneal limbal stem cells autograft transplantation together with mitomycin application and traditional simple excision under mi- croscope. Methods 46 eyes from 39 patients were involved in the present study and randomly divided into two groups, with 23 eyes in each group. Simple excision group only received microsurgerical resection of pterygium. Joint operation group underwent microscopical operation of pterygium excision, followed by the treatment of mitomyein （0.02% ） and corneal limbal stem cells autograft transplantation. Thereafter,all cases were followed up for 12 months, and the recurrence of pterygium was observed. Results Based on the 4 postoperative status of pterygium,2 recurrent cases were found in patients receiving the treatment of corneal limbal stem cells autograft transplantation combined with mitomycin application, but 8 cases in the group of simply mi- crosurgical resection. Conclusion Microsurgical excision combined with corneal limbal stem cells autograft transplantation and mitomycin application could significantly reduce the recurrence rate of pterygium compared with simply microsurgical oper- ation （ P 〈 O. 05 ）.