The effects of ingestion time of gliclazide in relationship to meals on plasma glucose,insulin and c-peptide levels |
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Authors: | J Batch A Ma D Bird R Noble B Charles P Ravenscroft D Cameron |
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Institution: | (1) Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia;(2) Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Australia |
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Abstract: | Summary The effect of altering the timing of gliclazide administration in relation to a meal was studied in ten type 2 (non-insulin
dependent) chronically treated diabetics. Gliclazide was given 30 min before, at the start of and 30 min after breakfast or
omitted altogether.
Plasma gliclazide was present at greater than 2 mg/l throughout the study periods. Administration at 30 min after the meal
significantly delayed the time to peak for plasma gliclazide. No significant difference was noted in plasma glucose, insulin
or c-peptide patterns with any protocol.
It is concluded that, in clinical practice, with chronically treated diabetics the timing of gliclazide ingestion in relation
to meals is not critical. |
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Keywords: | Gliclazide non-insulin dependent diabetes administration time plasma glucose insulin c-peptide |
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