| 周围型肺癌SCT征象与VEGF、E-cad表达相关性研究 |
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| 引用本文： | 宁培钢,高剑波,岳松伟,杨学华,周志刚,郭华,吴逸明,张永高.周围型肺癌SCT征象与VEGF、E-cad表达相关性研究[J].山东医药,2008,48(14):8-10. |
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| 作者姓名： | 宁培钢 高剑波 岳松伟 杨学华 周志刚 郭华 吴逸明 张永高 |
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| 作者单位： | 郑州大学第一附属医院,河南郑州,450052 |
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| 基金项目： | 国家自然科学基金资助项目(30571552). |
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| 摘 要： | 目的 讨周围型肺癌SCT征象与血管内皮生长因子（VEGF）、E钙黏附蛋白（E-cad）表达的关系。方法对58例周围型肺癌患者术前行螺旋CT（SCT）扫描，术后标本采用免疫组化SP法检测肿瘤组织中E-cad和VEGF蛋白表达。结果周围型肺癌中，胸膜侵犯、淋巴转移及TNM分期SCT诊断准确率分别为86．67％、88．24％和81．25％。肺癌E-cad的异常表达与肿瘤的大小、棘突征、胸膜侵犯及淋巴转移明显相关；VEGF的表达与周围型肺癌的毛刺征、棘突征、空洞征、胸膜侵犯、淋巴转移明显相关。结论SCT可清晰显示周围型肺癌的各种征象，较准确地反映肿瘤浸润转移的病理学和生物学特性。
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| 关 键 词： | 肺肿瘤 体层摄影术 X线计算机 血管内皮生长因子 E钙黏附蛋白 |
| 文章编号： | 1002-266X(2008)14-0008-03 |
| 修稿时间： | 2007年12月18 |
Correlation between spiral CT features and expression of VEGF,E-cad in peripheral pulmonary carcinoma |
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| NING Pei-gang,GAO Jian-bo,YUE Song-wei,YANG Xue-hua,ZHOU Zhi-gang,GUO Hua,WU Yi-ming,ZHANG Yong-gao.Correlation between spiral CT features and expression of VEGF,E-cad in peripheral pulmonary carcinoma[J].Shandong Medical Journal,2008,48(14):8-10. |
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| Authors: | NING Pei-gang GAO Jian-bo YUE Song-wei YANG Xue-hua ZHOU Zhi-gang GUO Hua WU Yi-ming ZHANG Yong-gao |
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| Institution: | NING Pei-gang,GAO Jian-bo,YUE Song-wei,YANG Xue-hua,ZHOU Zhi-gang,GUO Hua,WU Yi-ming,ZHANG Yong-gao(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,P.R.China) |
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| Abstract: | Objective To investigate the correlation between spiral-CT(SCT) features and expressions of VEGF,E-cad in peripheral pulmonary carcinoma(PPC).Methods 58 cases with pulmonary carcinoma confirmed were performed SCT within one week before surgery.Expressions of VEGF,E-cad of pulmonary carcinoma were examined with SP immunohistochemical technique.Results The rate of pleural invasion,lymph node metastasis and the TNM of tumor by SCT diagnosis was 86.67%,88.24% and 81.25%.The abnormal expression of E-cad was asso... |
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| Keywords: | lung neoplasms tomograph X-ray computed vascular endothelial growth factor E-cadherin |
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