| BMP诱导自体气管移植段软骨再生的量效关系 |
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| 引用本文： | 李小飞,张涛,程庆书,刘锟,卢强,汪健. BMP诱导自体气管移植段软骨再生的量效关系[J]. 医学争鸣, 2004, 25(5): 412-414 |
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| 作者姓名： | 李小飞 张涛 程庆书 刘锟 卢强 汪健 |
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| 作者单位： | 第四军医大学唐都医院胸外科,陕西,西安,710038;第四军医大学唐都医院胸外科,陕西,西安,710038;第四军医大学唐都医院胸外科,陕西,西安,710038;第四军医大学唐都医院胸外科,陕西,西安,710038;第四军医大学唐都医院胸外科,陕西,西安,710038;第四军医大学唐都医院胸外科,陕西,西安,710038 |
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| 基金项目： | 国家自然科学基金 (39970 70 7)，陕西省自然科学基金(99SM37) |
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| 摘 要： | 目的：将重组人骨形态发生蛋白-2(rhBMP-2)植入犬的自体异位气管移植段内诱发新生软骨，寻求rhBMP-2在气管移植段内诱发软骨的量效关系及最佳的rhBMP-2用量．方法：8只杂种犬，颈部切取5环气管段作为移植段．移植段各环间软组织中植入不同含量的rhBMP-2后埋入自体的腹腔大网膜中．不同含量的rhBMP-2均以胶原为缓释载体．术后4wk处死动物取材，并行大体及组织学观察．结果：各组移植段固有软骨环均被轻度吸收．rhBMP-2植入组移植段环间均有不同程度的软骨再生，且各组新生软骨量随植入物中rh—BMP之含量的增加而增加．结论：rhBMP-2可刺激气管移植段软骨再生，且存在量效关系，以每环间植入5mg的rhBMP-2较为合适．
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| 关 键 词： | 气管 移植 骨形态发生蛋白质 |
| 文章编号： | 1000-2790(2004)05-0412-03 |
| 修稿时间： | 2003-11-18 |
Dose-dependent effects of cartilage regeneration induced by BMP in tracheal autograft |
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| LI Xiao Fei,ZHANG Tao,CHENG Qing Shu,LIU Kun,LU Qiang,WANG Jian. Dose-dependent effects of cartilage regeneration induced by BMP in tracheal autograft[J]. Negative, 2004, 25(5): 412-414 |
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| Authors: | LI Xiao Fei ZHANG Tao CHENG Qing Shu LIU Kun LU Qiang WANG Jian |
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| Affiliation: | LI Xiao Fei,ZHANG Tao,CHENG Qing Shu,LIU Kun,LU Qiang,WANG Jian Department of Thoracic Surgery,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China |
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| Abstract: | AIM: To investigate the dose dependent effects of cartilage regeneration induced by rhBMP 2 in tracheal autograft. METHODS: Different concentration of rhBMP 2 was administrated to the canine trachea autograft, and then the autografts were heterotopically transplanted into the omentum. The autografts were harvested after 4 weeks and the morphologic changes of the autografts were observed by light microscope. The area of regeneration cartilage was measured. RESULTS: The area of regeneration cartilage increased along with the concentration of rhBMP 2 ( P < 0.05 ). But it increased slowly when the concentration of rhBMP 2 was above 5 mg ( P >0.05). CONCLUSION: These results indicate that 5 mg rhBMP 2 can be an appropriate dose in canine tracheal autografts. |
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| Keywords: | trachea transplantation bone morphogenetic protein |
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