Livin在萎缩性胃炎及消化道肿瘤中的研究进展 |
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引用本文: | 崔琴,白晓茹,屈振杰,陈吉.Livin在萎缩性胃炎及消化道肿瘤中的研究进展[J].疾病监测与控制杂志,2011(6):338-340. |
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作者姓名: | 崔琴 白晓茹 屈振杰 陈吉 |
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作者单位: | 内蒙古医学院第三附属医院消化内科,内蒙古包头014010 |
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摘 要: | Livin是最近发现的凋亡抑制蛋白家族新成员,在大多数正常成人组织低表达或不表达(除胎盘),而在一些恶性肿瘤中特异性高表达,与肿瘤的发生、发展及复发密切相关。其在慢性萎缩性胃炎及消化道肿瘤(如食管癌、胃癌)中的特征性变化具有一定的临床应用价值。本研究就近年来Livin对抗细胞凋亡机制,在慢性萎缩性胃炎及消化道肿瘤中的表达,在抗肿瘤治疗的成果及展望等方面的研究进展作一综述。
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关 键 词: | Livin 慢性萎缩性胃炎 消化道肿瘤 凋亡抑制蛋白 |
Livin in atrophic gastritis and intestinal tumors in Progress |
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Authors: | CUI Qin BAI Xiao-ru QU Zhen-jie CHEN Ji |
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Institution: | (Third Affiliated Hospital of Inner Mongolia Medical College of Gastroenterology,Baotou 014010,China) |
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Abstract: | Livin is a recently discovered new member of inhibitor of apoptosis protein family,in most normal adult tissues with low expression or no expression(except the placenta),and in the expression of a number of specific malignancies,with tumor development and recurrence closely related.In chronic atrophic gastritis and gastrointestinal tumors(such as esophageal cancer,gastric cancer)characteristic changes in the clinical application of a certain value.In this paper,mechanism of apoptosis in recent years against Livin,in chronic atrophic gastritis and gastrointestinal tumors,the results of the anti-tumor therapy and prospects of research reviewed in the paper. |
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Keywords: | Livin chronic atrophic gastritis gastrointestinal tumors apoptosis inhibitory protein |
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