| 葫芦素毫微粒冻干针剂的研究 |
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| 引用本文： | 李超英,侯世祥,阳长明,孙毅毅,张继芬.葫芦素毫微粒冻干针剂的研究[J].中国中药杂志,2001,26(5):315-317. |
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| 作者姓名： | 李超英 侯世祥 阳长明 孙毅毅 张继芬 |
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| 作者单位： | 华西医科大学药学院药剂教研室, |
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| 摘 要： | 目的 :制备稳定的、易再分散的葫芦素聚乳酸毫微粒 (Cu-PLA-NP)冻干针剂。方法 :选用适宜填充剂制备Cu-PLA-NP冻干针剂 ,并评价其相关理化性质。结果 :冻干前后毫微粒形态、粒径、pH、包封率及载药量无明显变化 ,再分散性良好 ,制剂稳定 ,含水量合格。其临界相对湿度为 69.52%。结论 :在适宜的处方及工艺条件下制备的Cu-PLA-NP冻干针剂是可行的。
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| 关 键 词： | 葫芦素 毫微粒 冻干针剂 质量评价 |
| 文章编号： | 1001-5302(2001)05-0315-03 |
| 收稿时间： | 2000/5/29 0:00:00 |
| 修稿时间： | 2000年5月29日 |
A Study on Lyophilization Injection of Cucurbitacin Polylactic Acid Nanoparticles |
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| LI Chao ying;HOU Shi xiang.A Study on Lyophilization Injection of Cucurbitacin Polylactic Acid Nanoparticles[J].China Journal of Chinese Materia Medica,2001,26(5):315-317. |
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| Authors: | LI Chao ying;HOU Shi xiang |
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| Institution: | School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, Sichuan, China. |
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| Abstract: | Objective:To prepare stable and redispersable Lyophilization injection of cucurbitacin polylactic acid nanoparticles(Cu-PLA-NP).Method:An optimal supporting agent was chosen to prepare the Cu-PLA-NP lyophilization injection.The physical and chemical properties of the injection were evaluated.Result:The shape,diameters,association ratio,drug loading and pH of Cu-PLA-NP colloidal solution and lyophilization injection were not changed.The content of water consisted with the requirement of lyophilization injection.The critical relative humidity was 69.52%.The stability was good.Conclusion:It is practicable to prepare Cu-PLA-NP lyophilization injection with proper formulas and preparation processes. |
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| Keywords: | cucurbitacin nanoparticles lyophilization injection evaluation |
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