| 瘦素基因G-2548A多态性与儿童肥胖症的相关性 |
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| 引用本文： | 吴华,林吉涛,陈晓芸,黄斯夫,潘良凤.瘦素基因G-2548A多态性与儿童肥胖症的相关性[J].中国热带医学,2009,9(7):1205-1206,1255. |
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| 作者姓名： | 吴华 林吉涛 陈晓芸 黄斯夫 潘良凤 |
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| 作者单位： | 南方医科大学附属深圳宝安医院,广东,深圳,518101 |
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| 基金项目： | 深圳市科技计划项目(项目编号:2005148) |
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| 摘 要： | 目的观察瘦素基因G-2548A多态性与儿童肥胖的关联性。方法197例汉族儿童，其中正常体重组68例，轻度肥胖组81例，中、重度肥胖组48例，采用PeR—RFLP方法对瘦素基因-2548位点的基因型进行检测，分析其多态性与各临床表型的相关性。结果在正常体重组与肥胖组间G-2548A基因型与等位基因频率的分布不存在显著性差异（P＞0．05）；在197例观察对象中，腰臀比在不同基因型组间有统计学差异（17=7．219,P=0．022），而BMI、血清瘦素在不同基因型组间的差异均无统计学意义。结论瘦素基因G-2548A多态性影响汉族肥胖儿童的局部脂肪分布。
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| 关 键 词： | 肥胖 儿童 瘦素基因 多态性 |
Correlation of polymorphism of leptin Gene G-2548A with obesity in children |
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| WU Hua,LIN Ji-tao,CHEN Xiao-yun,et al..Correlation of polymorphism of leptin Gene G-2548A with obesity in children[J].China Tropical Medicine,2009,9(7):1205-1206,1255. |
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| Authors: | WU Hua LIN Ji-tao CHEN Xiao-yun |
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| Institution: | Baoan District Hospital Affiliated to Nanfang Medical University;Shenzhen 518101;Guangdong;P.R.China |
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| Abstract: | Objective To observe the relationship between leptin gene polymorphism G-2548A and obesity or it's phenotype in Children.Methods The genotypes of leptin G-2548A in 197 children including 68 normal control,81 mild obesity and 48 relatively severe obesity were detected by PCR-RFLP.Results No difference was observed in frequency distribution of G-2548A genotypes and alleles between obesity group and normal group(P>0.05).There was a significant difference among different G-2548A genotype groups in WHR(F=7.219,P... |
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| Keywords: | Obesity Child Leptin gene Polymorphism |
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