Radiofrequency Thermal Ablation of Breast Cancer Local Recurrence: A Phase II Clinical Trial |
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Authors: | Jean-Rémi Garbay Marie-Christine Mathieu Michele Lamuraglia Nathalie Lassau Corrine Balleyguier Roman Rouzier |
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Institution: | (1) Department of Surgery, Pathology and Radiology, and the Breast Unit, Institut Gustave Roussy, Villejuif, France;(2) Department of Gynecology and Obstetrics, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France;(3) Unité Propre de Recherche de l’Enseignement Supérieur, Equipe d’Accueil 4053 of the University Pierre et Marie Curie, Paris VI, France |
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Abstract: | Background The role of radiofrequency (RF) ablation to treat local recurrence of breast cancer is unknown.
Methods We conducted a two-stage phase II clinical trial. Eligible patients had a histologically confirmed noninflammatory and ≤3 cm
ipsilateral breast tumor recurrence. The tumor site was identified by intraoperative sonography. A LeVeen needle electrode
(RadioTherapeutics Corp, Mountain View, Calif) was inserted into a single site within the tumor and radiofrequency ablation
was performed using a RF-2000 generator (RadioTherapeutics Corp). After completion of radiofrequency, a mastectomy was performed.
Conventional staining and nicotinamide adenine dinucleotide-diaphorase (NADH-diaphorase) cell viability staining were performed.
Results During the first stage, procedures were uneventful. Conventional, cytokeratin, and NADH-diaphorase staining identified persistent
viable tumor cells in the RF-ablated region in three patients. This phase II trial was stopped after completion of the first
stage because of insufficient efficacy.
Conclusion We demonstrate in this study that RF ablation is a potential technique to destroy local recurrence of breast tumors but the
technique we tested in this phase II clinical trial had insufficient efficacy to recommend its use in routine. |
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Keywords: | Breast cancer Local recurrence Radiofrequency ablation Breast conservation |
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