Changes in the serum antioxidant system and lipid peroxidation under the influence of asbestos |
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| Authors: | S. K. Soodaeva E. A. Ostrakhovich A. V. Kozlov B. T. Velichkovskii |
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| Affiliation: | (1) Laboratory of Free-Radical Mechanisms of Respiratory Organ Pathology Institute of Pulmonology, Russian Ministry of Public Health, Moscow;(2) Laboratory of Pathogenesis and Experimental Therapy of Pneumoconioses, N. I. Pirogov Russian State Medical Institute, Moscow |
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| Abstract: | The iron content, the state of the serum antioxidant system, and their relationship with the changes in lipid peroxidation in rat liver and lungs at the early stages of chrysotile-asbestos action, and the effect of the naturally occurring flavonoid rutin are studied. Intensification of lipid peroxidation in the liver and lungs and an increase in the oxyproline content, which correlates with the rise in serum antioxidant activity, are observed four weeks after a single intratracheal administration of 50 mg asbestos. The total serum iron content remains unchanged. Rutin has a pronounced anti-asbestos effect, inhibits the early stages of fibrosis, and facilitates normalization of the antioxidant system imbalance induced by asbestos. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N o 8 pp. 145–147, August, 1994 |
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| Keywords: | asbestos antioxidant activity ceruloplasmin transferrin rutin |
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