| 外源性LIF和IL-1对围着床期小鼠子宫内膜整合素β3亚基表达的调节 |
| |
| 引用本文： | 张炜,周剑萍,刘银坤,朱瑾.外源性LIF和IL-1对围着床期小鼠子宫内膜整合素β3亚基表达的调节[J].中国免疫学杂志,2001,17(2):93-95. |
| |
| 作者姓名： | 张炜 周剑萍 刘银坤 朱瑾 |
| |
| 作者单位： | 1. 上海医科大学妇产科医院,
2. 上海医科大学中山医院肝癌研究所, |
| |
| 基金项目： | 本课题受上海市卫生局科技基金资助(96429) |
| |
| 摘 要： | 目的研究外源性LIF及IL-1对围着床期子宫内膜整合素β
|
| 关 键 词： | 白血病抑制因子 白介素-1 整合素β |
| 文章编号： | 1000-484X(2001)02-0093-03 |
| 修稿时间： | 2000年6月29日 |
Regulation of external LIF
on the expression of integrin |
| |
| Abstract: | Objective:To study regulation of external leukemia inhibitory factor(LIF) and interlukin- 1(IL-1) on the expression of integrin β3 in the mouse endometrium during per i-implantation period and explore the mechanism which LIF participate in embryo ni c implantation.Methods:The mice were injected peritoneally with LIF,IL-1 or IL-1ra at different administration on day 2～4 of pregnancy .The level of integrin β3 protein was measured with Westernblot method and mR NA measured with RT-PCR.Results:The levels of integrin β 3 protein and mRNA were increased by LIF and IL-1(P＜0.05) and which reli ed o n administration.The level of integrin β3 mRNA was decreased by IL-1ra (P <0.05).Conclusion:LIF and IL-1 of cytokines can improve the expr ession of integrin β3 in the peri-implantation endometrium of mouse.Both of them may take part in implantation by regulating cell adhesion molecules. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
