| 局灶性脑缺血早期大鼠尾壳核生长抑素mRNA表达的变化 |
| |
| 引用本文： | 赵祥,赵健,熊克仁. 局灶性脑缺血早期大鼠尾壳核生长抑素mRNA表达的变化[J]. 皖南医学院学报, 2006, 25(1): 18-21 |
| |
| 作者姓名： | 赵祥 赵健 熊克仁 |
| |
| 作者单位： | 皖南医学院,解剖学教研室,安徽,芜湖,241001 |
| |
| 摘 要： | 目的观察早期脑缺血对大鼠尾壳核内生长抑素(SOM)mRNA表达的影响。方法采用原位分子杂交方法,观察大脑中动脉阻塞所致脑缺血1 h和6 h后大鼠尾壳核SOM mRNA表达的变化。结果脑缺血早期缺血侧大鼠尾壳核内SOM mRNA表达明显下降(P<0.01)。结论早期脑缺血对大鼠尾壳核SOM mRNA表达有明显的影响,提示SOM mRNA阳性神经元可能对脑缺血耐受性较差。
|
| 关 键 词： | 脑缺血 尾壳核 生长抑素 大鼠 |
| 文章编号： | 1002-0217(2006)01-0018-04 |
| 收稿时间： | 2005-08-02 |
| 修稿时间： | 2005-08-02 |
The expression of somatostatin mRNA in rat caudate nucleus during early stage of focal cerebral ischemia |
| |
| ZHAO Xiang,ZHAO Jian,XIONG Ke-ren. The expression of somatostatin mRNA in rat caudate nucleus during early stage of focal cerebral ischemia[J]. Acta Academiae Medicinae Wannan, 2006, 25(1): 18-21 |
| |
| Authors: | ZHAO Xiang ZHAO Jian XIONG Ke-ren |
| |
| Affiliation: | Department of Anatomy, Wannan Medical College, Wuhu 241001, China |
| |
| Abstract: | Objective To observe the effect of early cerebral ischemia on the expression of somatostatin(SOM) mRNA in rat caudate nucleus.Methods The middle cerebral arteries of rats were occluded for 1 hour or 6 hours by intraluminal sutures.The changes of SOM mRNA positive cells in rat caudate nucleus were examined after focal cerebral ischemia by using situ hybridization methods.Results The expression of SOM mRNA in caudate nucleus decreased sharply during the early stage of middle cerebral artery occlusion(MACO),the effect on MACO was more obvious in the 6 h group than that in the 1 h(P<0.01).Conclusion The findings suggest that SOM mRNA positive cells in rat caudate nucleus are vulnerable to result of cerebral ischemia. |
| |
| Keywords: | cerebral ischemia caudate nucleus somatostatin rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
