坛紫菜硫酸多糖对60Co辐射引起的小鼠体内氧化应激的作用研究

应用生物化学的方法探讨在^60Co辐射条件下，坛紫菜硫酸多糖对小鼠体内氧化应激的抑制作用。结果表明，^60Co辐射能显著降低昆明种小鼠体内不同脏器组织匀浆SOD、GSH—Px的活性，引起脂质过氧化。坛紫菜硫酸多糖可提高辐射损伤后小鼠组织匀浆SOD、GSH—Px的活性，增强总抗氧化能力，减少脂质过氧化。

Antioxidative activity of polysaccharide fraction from Porphyra haitanensis on oxidative stress in mice irradiated by 60Co

Sulfated polysaccharide from Porphyra haitanensis showed inhibitory effect on the lipid peroxidation in vitro. In the present study, the changes in the antioxidative enzyme activity, lipid peroxidation, and total antioxidative capacity (T-AOC) in different organs after 60 Co irradiation were detected in mice by using biochemical methods. Increased endogenous lipid peroxidation and decreased contents of T-AOC as well as decreased activities of super-oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were observed in mice after 60Co irradiation. Intraperitoneal administration of polysaccharide fraction F2 significantly decreased the lipid peroxidation. F2 treatment increased T-AOC and the activities of SOD and GSH-Px in all organs tested in 60Co irradiated mice. It is concluded that the sulfated polysaccharide fraction F2 from Porphyra haitanensis can be used in compensating the decline in antioxidative capacity arising from radiotherapy and thereby reduced the risks of lipid peroxidation.