| ANA、抗ENA抗体联合检测对自身免疫病诊断的意义 |
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| 引用本文： | 牟君成,陈联,王文昕,杨晓匿. ANA、抗ENA抗体联合检测对自身免疫病诊断的意义[J]. 重庆医学, 2009, 38(18) |
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| 作者姓名： | 牟君成 陈联 王文昕 杨晓匿 |
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| 作者单位： | 重庆三峡中心医院微生物免疫科,万洲,404000;重庆三峡中心医院微生物免疫科,万洲,404000;重庆三峡中心医院微生物免疫科,万洲,404000;重庆三峡中心医院微生物免疫科,万洲,404000 |
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| 摘 要： | 目的 探讨抗核抗体(ANA)和抗可提取性核抗原(ENA)多肽抗体谱检测对自身免疫病诊断的意义.方法 对285例各种自身免疫病患者和30例健康人血清采用间接免疫荧光法检测ANA,免疫印迹法检测ENA多肽抗体.结果 ANA在SLE患者中最高,阳性率为97.1%;抗SSA、抗SSB 抗Sm、抗dsDNA、抗NUC和抗ulRNP抗体在SLE中检出率分别为85.6%,75.3%,37.4%,90.8%,83.3%和77.6%;抗SSA、抗SSB和抗ulRNP在SS中检出率分别为84.8%,78.8%和69.7%;抗Jo-1抗体在PM/DM中检出率为52.6%;抗ulRNP抗体在MCTD中检出率为90.5%;抗Scl-70抗体在PSS中检出率为46.7%.结论 ANA和ENA抗体谱阳性分布有明显的倾向性,不同的自身免疫病患者血清所含自身抗体有差异,因此ANA和ENA抗体联合检测对自身免疫病具有诊断意义.
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| 关 键 词： | 抗核抗体 自身抗体 自身免疫病 诊断 |
Diagnostic value of combined detection of ANA,anti-ENA antibody to autoimmune diseases |
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| MOU Jun-cheng,CHEN Lian,WANG Wen-xin,et al.. Diagnostic value of combined detection of ANA,anti-ENA antibody to autoimmune diseases[J]. Chongqing Medical Journal, 2009, 38(18) |
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| Authors: | MOU Jun-cheng CHEN Lian WANG Wen-xin et al. |
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| Affiliation: | MOU Jun-cheng,CHEN Lian,WANG Wen-xin,et al.(Department of Microbiology , Immunology,Chongqing Three Gorges Central Hospital,Wanzhou,Chongqing 404000,China) |
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| Abstract: | Objective To evaluate the diagnostic value of combined ANA and anti-ENA autoantibody profiles to autoimmune diseases.Methods Indirect immunological fluorescence method for ANA,Western-blot for ENA were combined to examine 285 serum samples from the autoimmune diseases patients and 30 healthy adults.Results The positive rates of ANA was 97.1% in the patients with SLE;anti-SSA,anti-SSB,anti-Sm,anti-dsDNA,anti-NUC and anti-ulRNP autoantibody were 85.6%,75.3%,37.4%,90.8%,83.3% and 77.6% in the patients with SLE... |
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| Keywords: | ANA autoantibody autoimmune diseases diagnosis |
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