调脂联合降压对高血压病患者动态血压及其平滑指数的影响

目的：观察阿托伐他汀联合贝那普利降压治疗对老年人动态血压及其平滑指数（SI）的影响。方法：180例诊断为原发性高血压的老年患者被随机分为贝那普利降压组和调脂降压联合治疗组，调脂降压联合治疗组在贝那普利降压基础上加用阿托伐他汀10mg，1次／d，所有病人均于治疗前及治疗6个月后行血脂及动态血压检查，记录24h平均收缩压（24hSBP）及24h平均舒张压（24hDBP），计算24h收缩、舒张压平滑指数（SISBP和SIDBP）及脉压（PP）、脉压指数（PPI），比较两组病人治疗前后血脂、动态血压值及其稳定性的变化。结果：6个月后，两组患者血压控制良好，与治疗前比较，联合治疗组总胆固醇（5．79±0．5）mmol／L比（3．78±0．11）mmol／L]、甘油三酯（1．81±0．27）mmol／L比（1．22±0．1）mmol／L]水平明显降低（P〈0．01）；与单纯降压组比较，PP（51±10）mmHg比（45±8）mmHg]及PPI（0．38±0．05）mmHg比（0．35±0．08）mmHg]明显降低（P〈0．05），而SISBP（1．26±0．2）mmol／L比（1．37±0．16）mmol／L]和SIDBP（1．18±0．23）mmol／L比（1．28±0．14）mmol／L]明显升高（P〈0．05～0．01）。结论：降压协同阿托伐他汀降脂治疗能更降低动态血压的脉压及脉压指数，并且明显提高血压平滑指数。

Effects of atorvastatin combined benazepril on ambulatory blood pressure and its smoothness index in aged patients with essential hypertension

Objective:To observe effects of atorvastatin combined benazepril on ambulatory blood pressure and its smoothness index(SI) in aged patients with essential hypertension(EH).Methods:A total of 180 aged patients diagnosed as EH were randomly divided into benazepril group and benazepril + atorvastatin group,benazepril + atorvastatin group were given atorvastatin 10 mg,once a day based on antihypertensive treatment with benazepril.For all patients,blood lipid and ambulatory blood pressure were measured.SI of 24h...