Antigen-receptor degeneracy and immunological paradigms |
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Authors: | Cohen Irun R Hershberg Uri Solomon Sorin |
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Affiliation: | The Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel. irun.cohen@weizmann.ac.il |
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Abstract: | This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones. |
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