来氟米特与甲氨喋呤对照治疗类风湿关节炎160例

目的：观察来氟米特（leflunomide,LEF)治疗类风湿关节炎（RA）的疗效和安全性，并用甲氨蝶(methotrexate,MTX)作对照。方法：160例活动性RA患者随机分为23组，每组各80例，用随机双盲方法分别服用LEF20MG.D^-1,或TMX15mg/周，疗程均为24周，比较观察其疗效和不良反应。结果：经治疗24周后，LEF组有效率和显效率分别为81．54％和36．92％，MTX组分别为75．81％和35．48％。不良反应发生率LEF组和TMX组分别为15．39％和26．47％。2组疗效和不良反应发生率均无明显判别，但LEF组的不良反应程度明显较MTX组轻，结论：LEF治疗RA的疗效肯定，且具有料好的耐受性。

Randomized double blind controlled study of leflunomide intreatment of rheumatoid arthritis

Objective:To evaluate the safety and efficacy of leflunomide(LEF)in comparison with methotrexate(MTX)in treatment of rheumatoid arthritis (RA).Methods:160 patients with active RA were equally divided to receive 20 mg daily LEF or 15 mg weekly MTX for 24 weeks and their efficacy and adverse events were observed.Results:The effective rate and significantly effective rate for LEF group were 81.54% and 36.92% respectively and for MTX group were 75.81% and 35.48% respectively with no significant difference between groups.The incidence of adverse events for LEF and MTX groups were 15.39% and 26.47% respectively,also no significant difference.Conclusion:LEF is an effective agent for treatment of RA with better tolerability.