| GRIM-19蛋白在乳腺癌组织中的表达 |
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| 引用本文： | 翟娜娜,黄器伟,陈奎生,刘军伟,李喜强. GRIM-19蛋白在乳腺癌组织中的表达[J]. 肿瘤基础与临床, 2014, 0(6): 470-472 |
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| 作者姓名： | 翟娜娜 黄器伟 陈奎生 刘军伟 李喜强 |
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| 作者单位： | 1. 黄河科技学院医学院,河南 郑州,450063
2. 郑州大学第一附属医院,河南 郑州,450052 |
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| 基金项目： | 河南省基础与前沿技术研究项目 |
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| 摘 要： | 目的：探讨干扰素/维甲酸联合应用诱导的细胞凋亡相关基因19（ GRIM-19）在乳腺癌组织中的表达，分析其与乳腺癌的关系。方法应用免疫组化S-P法检测50例正常乳腺组织及50例乳腺癌组织中GRIM-19蛋白的表达。结果乳腺癌组织中GRIM-19蛋白的阳性表达率为26.00%，明显低于正常乳腺组织的84.00%（P〈0.05）；GRIM-19蛋白表达水平与乳腺癌TNM分期和组织分化程度有关（P〈0.05）。结论 GRIM-19的低表达可能与乳腺癌的发生发展密切相关。
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| 关 键 词： | 乳腺癌 免疫组化 干扰素/维甲酸联合应用诱导的细胞凋亡相关基因 |
Expression of GRIM-19 Protein in the Breast Cancer |
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| Zhai Nana,Huang Qiwei,Chen Kuisheng,Liu Junwei,Li Xiqiang. Expression of GRIM-19 Protein in the Breast Cancer[J]. Journal of Basic and Clinical Oncology, 2014, 0(6): 470-472 |
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| Authors: | Zhai Nana Huang Qiwei Chen Kuisheng Liu Junwei Li Xiqiang |
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| Affiliation: | Zhai Nana, Huang Qiwei, Chen Kuisheng, Liu Junwei, Li Xiqiang ( 1. Medical School, Huanghe Science and Technology College, Zhengzhou 450063, China ; 2. The First Affiliated Hospital ,Zhengzhou University,Zhengzhou 450052, China) |
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| Abstract: | Objective To investigate the expression of gene associated with retinoid-interferon-induced mortality-19（GRIM-19）protein in the breast cancer and the correlation with breast cancer. Methods Immunohistochemis-try S-P method was used to test the expression of GRIM-19 protein in the 50 cases of breast cancer and the 50 cases of normal gland tissues. Results The positive expression rate of GRIM-19 protein in the breast cancer（26. 00%） was significantly lower than that in the normal gland tissues（84. 00%）（P〈0. 05）. The expression of GRIM-19 protein was correlated with the TNM stage and histological grading of breast cancer（P〈0. 05）. Conclusion The low level expression of GRIM-19 protein was closely related with the tumor development and prognosis of breast cancer. |
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| Keywords: | breast cancer immunohistochemistry gene associated with retinoid-interferon-induced mortality-19 |
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