拉贝洛尔和尼卡地平治疗主动脉夹层时高血压的疗效比较

目的:评估静脉应用拉贝洛尔或尼卡地平治疗主动脉夹层时高血压的疗效及安全性。方法:60例主动脉夹层伴高血压者随机接受拉贝洛尔或尼卡地平治疗。结果:治疗10min平均动脉压下降10%~15%者,拉贝洛尔组为38%,尼卡地平组为45%(P>0.05);30min后血压控制在120/80mmHg以下者,拉贝洛尔组为93%,尼卡地平组为90%(P>0.05);治疗后10min平均心率下降拉贝洛尔组((77±7)次.min-1)较尼卡地平组((83±10)次.min-1)明显(P<0.05)。结论:拉贝洛尔或尼卡地平均可有效控制主动脉夹层时血压,拉贝洛尔单独静脉使用较尼卡地平单用更适合此临床急症。

Labetalol vs.Nicardipine for Hypertension in Patients with Acute Aortic Dissection

OBJECTIVE:To evaluate the efficacy and safety of intravenous labetalol or intravenous nicardipine for hypertension associated with aortic dissection.METHODS:A total of 60 patients with aortic dissection-related hypertension were randomly assigned to receive intravenous labetalol or nicardipine.RESULTS:Treatment response(10%～15% decrease in mean arterial pressure in 10 minutes treatment) was achieved in 38% of labetalol-treated patients and in 45% of nicardipine-treated group(P>0.05).After 30 minutes treatment,93% patients in labetalol group reached goal blood pressure(<120/80mmHg),compared with 90% in nicardipine group(P>0.05).However,tachycardia was significantly(P<0.05) more frequent in nicardipine group((83±10)beats per minute) than in labetalol group((77±7)beats per minute).CONCLUSION:Both labetalol and nicardipine can effectively keep the blood pressure under control in patients with acute aortic dissection.However,intravenous labetalol alone is more suitable than intravenous nicardipine alone in this clinical emergency case.