Role of different lymphocyte subpopulations in the formation of non-specific immunoglobulins induced by antigen injection |
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| Authors: | Chernyshova I N Borisova T K Emelyanzeva J A Sidorova E V |
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| Affiliation: | Institute for Viral Preparations of Russian Academy of Medical Sciences, Moscow. |
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| Abstract: | The formation of antibody and non-specific immunoglobulin under the influence of T-dependent (TD) and type 2 T-independent (TI-2) antigens in mice of two congenic strains CBA (Lyb5-, Lyb5+) and CBA/N (Lyb5-) was studied. TD antigens induced in mice of both strains not only the appearance of antibody-forming cells (AFC), but also a great increase in the number of cells producing non-specific immunoglobulins (nIFC). TI-2 antigens induced the AFC and antigen-dependent nIFC formation in CBA mice only. It is concluded that during immune response to TI-2 antigens not only the AFC appearance but the increase in nIFC formation (polyclonal activation) is due mainly to the mature Lyb5+ B cells. |
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