不同性别心绞痛患者肌钙蛋白I和脑利钠肽检测的临床意义

目的探讨不同性别心绞痛患者血浆心肌肌钙蛋白I(cTnI)和脑利钠肽(BNP)水平检测的临床意义。方法入选心绞痛患者283例,对照组64例。入院时测定血浆cTnI、BNP,并根据性别、冠状动脉造影结果、心绞痛类型及不稳定型心绞痛(UAP)Braunwald危险分级进行分组分析。结果男性UAP组、BraunwaldⅡ级组、BraunwaldⅢ级组cTnI[分别为(0.113±0.102)ng/L、(0.131±0.111)ng/L、(0.133±0.118)ng/L]明显高于女性对应各组[分别为(0.065±0.047)ng/L、(0.063±0.037)ng/L(、0.076±0.070)ng/L],而且在男性中,UAP组cTnI明显高于稳定型心绞痛(SAP)[(0.056±0.014)ng/L]组和对照组[(0.050±0.002)ng/L],BraunwaldⅢ级组和BraunwaldⅡ级组cTnI明显高于BraunwaldⅠ级组[(0.072±0.055)ng/L];女性各组BNP均明显高于男性对应各组,而且在女性中,UAP组BNP[(92.00±32.72)ng/L]明显高于SAP组[(43.21±14.20)ng/L]和对照组[(37.86±9.27)ng/L],BraunwaldⅢ级组和BraunwaldⅡ级组BNP[(115.20±44.73)ng/L、(89.04±13.92)ng/L]明显高于BraunwaldⅠ级组[(73.98±17.65)ng/L],BraunwaldⅢ级组BNP明显高于BraunwaldⅡ级组。结论心绞痛患者BNP和cTnI的表达存在性别差异;男性患者cTnI水平与心绞痛的类型及其危险层次明显相关;女性患者BNP水平与心绞痛的类型及其危险层次明显相关。

Clinical significance of plasma cardiac troponin I and brain natriuretic peptide level measurements in different gender patients with angina pectoris

Objective To explore the clinical significance of plasma cardiac troponin I(cTnI) and brain natriuretic peptide(BNP) level measurements in different gender patients with angina pectoris(AP). Methods Two hundred and eighty three patients with AP were enrolled,including 165 male and 118 female,64 healthy as controls were also selected.Venous blood samples were collected and plasma cTnI and BNP levels were assayed on admission. Results The cTnI levels of UAP group,Braunwald's grade Ⅱ group,Braunwald's grade Ⅲ group in male were significantly higher than that in female.In male,cTnI level in unstable angina pectoris(UAP)group was significantly elevated compared to the stable angina pectoris(SAP) group and control group;cTnI levels in Braunwald's grade Ⅱ group and Braunwald's grade Ⅲ group were significantly higher than that in Braunwald's grade Ⅰgroup.BNP levels of any group in female was significantly higher than that in male.In female,BNP level in UAP group was significantly higher than that in SAP group and control group;BNP levels in Braunwald's grade Ⅱ group and Braunwald's grade Ⅲ group were significantly higher than that in Braunwald's grade Ⅰ group;BNP level in Braunwald's grade Ⅲ group was significantly higher than that in Braunwald's grade Ⅱ group.Conclusions In AP patients,plasma cTnI and BNP levels are different by gender.In male patients,plasma cTnI level is closely correlated to the type and risk level of AP while in female patients,plasma BNP level is the responsible one to the type and risk level of AP.