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78例NSCLC血清VEGF表达临床意义分析
引用本文:刘新姿,钱晓萍,王朝霞,王科明,刘宝瑞,胡文静,王立峰,杨阳,禹立霞. 78例NSCLC血清VEGF表达临床意义分析[J]. 中国医药科学, 2011, 0(23): 17-19,33
作者姓名:刘新姿  钱晓萍  王朝霞  王科明  刘宝瑞  胡文静  王立峰  杨阳  禹立霞
作者单位:南京医科大学第二附属医院肿瘤科;南京大学附属鼓楼医院肿瘤中心
基金项目:2009年度南京医科大学第二附属医院青年科技启动基金项目(QN200915)
摘    要:目的检测非小细胞肺癌患者化疗前外周血血管内皮生长因子的水平,探讨其与化疗疗效、预后的关系。方法酶联免疫吸附试验检测78例NSCLC患者化疗前血清VEGF水平,并采用x2检验、Kaplan-Meier生存曲线比较与VEGF表达相关因素及其对生存期的影响。结果在NSCLC中,血清VEGF阳性率为30.8%(24/78)。VEGF的表达与淋巴结转移、远处转移、TNM分期、化疗疗效密切相关,但与年龄、性别、病理类型等无关。VEGF阳性组的生存期与阴性组相比接近统计学意义(P=0.0741)。结论检测NSCLC患者外周血VEGF,可能有利于协助预测转移、评价化疗疗效及判断预后。

关 键 词:非小细胞肺癌  VEGF  预后

Clinical significance of serum VEGF in 78 patients with non-small cell lung cancer
LIU Xinzi,QIAN Xiaoping,WANG Zhaoxia,WANG Keming,LIU Baorui,HU Wenjing,WANG Lifeng,YANG Yang,YU Lixia. Clinical significance of serum VEGF in 78 patients with non-small cell lung cancer[J]. China Medicine and Pharmacy, 2011, 0(23): 17-19,33
Authors:LIU Xinzi  QIAN Xiaoping  WANG Zhaoxia  WANG Keming  LIU Baorui  HU Wenjing  WANG Lifeng  YANG Yang  YU Lixia
Affiliation:1.Department of Oncology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;2.The Tumor Center of Gulou Hospital Affiliated to Medical College of Nanjing University,Nanjing 210008,China
Abstract:Objective To measure serum levels of VEGF in non-small cell lung cancer(NSCLC)patients and evaluate their prognostic value.Methods The serum levels of VEGF,in 78 cases with NSCLC were measured by ELISA before chemotherapy.Expression differences of VEGF and its relationship with the patients'survival were analyzed with x2 test,Kaplan-Meier survival curve.Results VEGF expression were found in 24 cases(30.8%).The serum levels of VEGF in patients before chemotherapy were significantly correlated to the lymph node metastasis,the distant metastasis,the TNM stage and the curative effect.No correlation was found among the expression of VEGF and the following clinical parameters such as age,sex,histological subtype.The differnnces of survival time between VEGF positive and negative expression NSCLC patients were approximate significant(P=0.074 1).Conclusion The measurement of serum levels of VEGF in advanced NSCLC is helpful for prediction of metastasis tendency and evaluation of prognosis.
Keywords:Non-small cell lung cancer  VEGF  Prognosis
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