纳洛酮治疗重度窒息新生儿疗效观察

目的探讨纳洛酮治疗重度窒息新生儿的疗效。方法将86例重度窒息新生儿随机分成2组，2组均采用综合对症支持治疗，治疗组52例生后1min即予纳洛酮脐静脉注射，并持续静脉滴注6h，2次／d，连用7d，观察和比较两组的Apgar评分及惊厥、呼吸衰竭、重度HIE发生率。结果治疗组Apgar评分明显高于对照组（P〈0．05），惊厥、呼吸衰竭、重度HIE发生率明显低于对照组（P〈0．05），差异有统计学意义。结论对重度窒息新生儿在对症支持治疗基础上尽早并持续使用纳洛酮，能缩短复苏时间，减少并发症发生率。

Observation of clinical effects of naloxone in newborn with severe asphyxia

Objective To observe the clinical effects of naloxone in newborn with severe asphyxia. Methods 86 newborns with severe asphyxia were randomly divided into 2 groups, both of them were given resuscitation and symptomatic treatment, 52 newborns were IV naloxone by umbilical vein at 1 min and continueous IV naloxone 6 h twice a day for 7 days. Apgar scores ,occurrences of seizure, respiratory failure, severe hypoxic ischemic encephalopathy(HIE) were observed to estimate the effects of treatment. Results Apgar scores of treatment group was significantly higher than control group(P<0.05). The occurrences of seizure , respiratory failure, severe HIEwere significantly lower in naloxone group than control group(P<0.05). Conclusion The continueous administration of naloxone as soon as possible in newborn with severe asphyxia can shorter of duration of resuscitation ,and decrease occurrences of complications.