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A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury |
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| Authors: | R Hausmann A Kaiser C Lang M Bohnert P Betz |
| Institution: | Department of Legal Medicine, University of Erlangen-Nürnberg, Universit?tsstrasse 22, D-91054 Erlangen, Germany, DE Institute of Pathology, Klinikum Nürnberg – Nord, Flurstrasse 17, D-90419 Nürnberg, Germany, DE Department of Legal Medicine, University of Würzburg, Versbacher Strasse 3, D-97078 Würzburg, Germany, DE Department of Legal Medicine, University of Freiburg, Albertstrasse 9, D-79104 Freiburg, Germany, DE |
| Abstract: | The time-dependent inflammatory cell reaction in human cortical contusions has been investigated during the first 30 weeks after blunt head injury. Immunohistochemical staining was carried out using CD 15 for granulocytes and LCA, CD 3 and UCHL-1 for mononuclear leucocytes. In order to provide reliable data for a forensic wound age estimation, the intensity of the cellular reaction was evaluated with a quantitative image analysis system. CD 15-labelled granulocytes were detectable earliest 10 min after brain injury, whereas significantly increased numbers of mononuclear leucocytes occurred in cortical contusions after a postinfliction interval of at least 1.1 days (LCA), 2 days (CD 3) or 3.7 days (UCHL-1), respectively. Received: 15 June 1998 / Received in revised form: 6 October 1998 |
| Keywords: | Brain injury Cortical contusion Inflammatory reaction Immunohistochemistry Wound age |
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