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Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States |
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| Authors: | Armin Rashidi Meghan Riley Teresa A. Goldin Farzaneh Sayedian Michael G. Bayerl Nadine S. Aguilera Jeffrey A. Vos Ranjit K. Goudar Stephen I. Fisher |
| Affiliation: | 1. Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, United States;2. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States;3. Department of Pathology, University of Virginia, Charlottesville, VA, United States;4. Department of Pathology, West Virginia University, Morgantown, WV, United States;5. Virginia Oncology Associates, Norfolk, VA, United States;6. Pathology Sciences Medical Group/Sentara Laboratory Services, Norfolk, VA, United States |
| Abstract: | Early death (ED) occurs in 10–30% of patients with acute promyelocytic leukemia (APL). Is all-trans retinoic acid (ATRA) promptly given and does it decrease overall early mortality? ATRA was administered within 24 h of morphological suspicion in only 44% of the 120 consecutive patients treated in the four collaborating centers. Absence of disseminated intravascular coagulation (p = 0.012) and admission to a non-university-affiliated hospital (p = 0.032) were independent predictors of ATRA delay. ED occurred in 17% of patients, and was independently correlated only with ICU admission (p = 0.002). Our results do not demonstrate that prompt (versus delayed) ATRA administration decreases overall early death. |
| Keywords: | ATRA Death Leukemia Promyelocytic |
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