The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis |
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| Authors: | Tatsuya Kondo Sayaka Kitano Nobukazu Miyakawa Takuro Watanabe Rieko Goto Miki Sato Satoko Hanatani Masaji Sakaguchi Motoyuki Igata Junji Kawashima Hiroyuki Motoshima Takeshi Matsumura Eiichi Araki |
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| Affiliation: | 1.Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Japan; 2.Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan |
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| Abstract: | The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-like peptide (GLP)-1 receptor agonist (RA) dramatically improved his glucose control. Levels of GLP-1 or gastric inhibitory polypeptide (GIP) were low at the baseline in the duodenum and serum of the patient. After 11 months of GLP-1RA treatment, his HbA1c worsened again, and intensive insulin therapy was necessary to control his glucose levels. Our report may explain the significance of residual incretin for maintaining the pancreatic β-cell function. |
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| Keywords: | colectomy diabetes glucagon-like peptide (GLP)-1 gastric inhibitory polypeptide (GIP) |
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