Preparation of arsenic trioxide albumim microspheres and its release characteristicsin vitro |
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Authors: | Zhou Jie Zeng Fuqing Gao Xiang Xie Shusheng Wei Shuli |
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Affiliation: | (1) Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China;(2) Laboratory of Immunopharmacology, Health Science Center, Peking University, 100083 Beijing, China;(3) Faculty of Pharmacy, Health Science Center, Peking University, 100083 Beijing, China |
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Abstract: | Summary Arsenic trioxide albumin microspheres (As2O3-BSA-NS) were prepared by using methods of chemical cross-linking. The desirability function (DF), calculated according to the size (<1μm) distribution, drug loading and drug trapping efficiency, was introduced as a total index for the microspheres formulation. Four factors, inculding W/O ratio, decentralization speed, BSA concentration and stirring stabilization time, were selected and arranged in an orthogonal experimental table. The release characteristic was studied by the drug release experimentin vitro. The four factors affected DF differently. Decentralization speed behaved as the maximum (P<0.01), followed by BSA concentration (P<0.05) and the W/O ratio dose (P<0.05). Stirring stabilization time did not influence DF (P>0.05). The release experimentin vitro showed that As2O3 in As2O3-BSA-NS was released more slower than pure As2O3. It was concluded that regular As2O3-BSA-NS may be prepared by the methods of chemical cross-linking, which was optimized by orthogonal experimental analysis of different factors, and the microspheres can release As2O3 slowly. ZHOU Jie, male, born in 1975, M.D., Ph.D. This project was supported by State Youth Natural Sciences Foundation (No. 30200284). |
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Keywords: | Arsenic trioxide Albumin microspheres chemical cross-linking slow release |
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