Molecular mechanisms of gamete recognition and fusion at fertilization |
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Authors: | Brewis IA; Moore HD |
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Institution: | Department of Molecular Biology and Biotechnology, The University of Sheffield, and Jessop Hospital for Women, UK. |
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Abstract: | Advances in many areas of reproductive technology have been rapid and, in
many respects, have outstripped our knowledge of the fundamental processes
of human and animal sperm-egg interactions at fertilization. This is
particularly true of human fertilization, where the availability of eggs
for research purposes is severely restricted. As a consequence of this,
most of the significant advances in our understanding of mammalian
fertilization have resulted from studies on animals, particularly the
mouse. This review summarizes our current knowledge of the molecular
aspects of mammalian fertilization from the point of view of the
fertilizing spermatozoon. Particular reference is made to those advances in
our knowledge of human fertilization mechanisms. Further understanding of
the molecular basis of human fertilization is of paramount importance for
the development of new methods of contraception and also for the rational
diagnosis and treatment of certain forms of infertility.
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