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| 帕金森病患者不同脑区质子磁共振波谱研究 | |
| 引用本文： | 丁正同,蒋雨平,王坚,杨莉芹,邬剑军,汪昕,耿道颖. 帕金森病患者不同脑区质子磁共振波谱研究[J]. 中国临床神经科学, 2003, 11(4): 346-350 |
| 作者姓名： | 丁正同 蒋雨平 王坚 杨莉芹 邬剑军 汪昕 耿道颖 |
| 作者单位： | 1. 复旦大学附属华山医院神经科,200040 2. 中山医学院附属中山医院神经科,200032 3. 复旦大学附属华山医院放射科,200040 |
| 基金项目： | 国家“十五”攻关课题资助项目(No:2001BA702B02) |
| 摘 要： | 目的:探讨~1H-MRS对早期PD的诊断价值。方法:采用~1H-MRS技术检测早期PD、晚期PD、帕金森综合征、偏侧ET以及年龄匹配的正常对照组基底节区和皮质运动区感兴趣区的NAA/Cr和Cho/Cr比值。结果:早期或晚期PD、偏侧ET及帕金森综合征患者受累较重基底节区或运动皮质区NAA/Cr及Cho/Cr比值与受累较轻侧相比无显著性差异;上述各组患者受累较重基底节区或运动皮质区NAA/Cr及Cho/Cr比值与正常对照组相应感兴趣区NAA/Cr及Cho/Cr比值相比也均无显著性差异。结论:~1H-MRS无助于早期PD的诊断。 |
| 关 键 词： | 帕金森病 质子磁共振波谱 N-天门冬胺酸/肌酸 胆碱/肌酸 |
| 文章编号： | 1008-0678(2003)04-0346-05 |
| 修稿时间： | 2003-09-20 |
Proton Magnetic Resonance Spectroscopy of Motor Cortex and Basal Ganglia in Patients with Parkinson''''s Disease |
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| DING Zheng-Tong,JIANC Yu-Ping,WANG Jian,YANG Li-Qin,WU Jian-Jun,WANG Xin,GENG Dao-Ying. Proton Magnetic Resonance Spectroscopy of Motor Cortex and Basal Ganglia in Patients with Parkinson''''s Disease[J]. Chinese Journal of Clinical Neurosciences, 2003, 11(4): 346-350 | |
| Authors: | DING Zheng-Tong JIANC Yu-Ping WANG Jian YANG Li-Qin WU Jian-Jun WANG Xin GENG Dao-Ying |
| Affiliation: | DING Zheng-Tong,JIANC Yu-Ping,WANG Jian,YANG Li-Qin,WU Jian-Jun,WANG Xin,GENG Dao-Ying Department of Neurology,Department of X-Ray,Huashan Hospital,Shanghai,200040,Depaitment of Neurology,Zhongshan Hospital,Fudan University,Shanghai,200040 |
| Abstract: | Aim:To explore the diagnostic value of proton magnetic resonance spectroscopy (1H-MRS)for early stage patients with Parkinson's disease. Methods: The NAA/Cr ratio and Cho/Cr of basal ganglia and motor cortex were determined by proton magnetic resonance spectroscopy among patients with early stage Parkinson's disease, among patients with advanced Parkinson s disease, in patients with parkinsonism, in patients with essential tremor with one side limbs involved and in age-matched control. Results: No significant differences were found between the more affected basal ganglia and motor cortex and the less affected basal ganglia and motor cortex when the NAA/Cr and Cho/Cr ratios were compared in any group patients, and there were also no significant differences to be found when the NAA/Cr and Cho/Cr ratios in the more affected basal ganglia and motor cortex of any group patients were compared with those in the basal ganglia and motor cortex of the control. Conclusion: 1H-MRS isn' t helpful for the diagnosis of early stage patients with Parkinson' s disease. |
| Keywords: | Parkiason's disease 1H-MRS NAA/Cr Cho/Cr |
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